Bioanalytic
Home
Contact
Products
Applications
Literature about Mithras LB 940 Multimode Reader

HTRF® & BRET: Schroeder et al.(2008):
   The C-terminal tail of CRTH2 is a key molecular determinant that constrains GalphaI- and downstream-signaling cascade activation; J. Biol. Chem 10.1074/jbc.M806867200
BRET: Langane et al.(2008):
  CXCR4 dimerization and β-arrestin–mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome; Blood, 1 July 2008, Vol. 112, No. 1, pp. 34-44
Fluorescence Polarisation: Burgevin et al.(2008):
  A Detailed Analysis of the Murine TAP Transporter Substrate Specificity; PLoS ONE, 1 June 2008, Volume 3, Issue 6

BRET: Perroy et al.(2008):
  Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors; J. Biol. Chem., Vol. 283, Issue 11, 6799-6805, March 14, 2008
BRET: Jorgensen et al.(2008):
  Characterization of G-Protein Coupled Receptor Kinase Interaction with the Neurokinin-1 Receptor Using Bioluminescence Resonance Energy Transfer; Mol Pharmacol 73:349-358, 2008
Fluorescence: Roccaro et al.(2008):
  Dual targeting of the proteasome regulates survival and homing in Waldenstrom's Macroglobulinemia; Blood DOI 10.1182/blood-2007-11-120972
Cytotoxicity Assay: Raftery et al.(2008):
  Inhibition of CD1 Antigen Presentation by Human Cytomegalovirus; J. Virol. doi:10.1128/JVI.01447-07
Luciferase Assay: Adamson et al.(2008):
  Human Prolactin Gene Promoter Regulation by Estrogen: Convergence with Tumor Necrosis Factor-alpha-Signaling; Endocrinology Vol. 149, No. 2 687-694
BRET: Coulon et al.(2008):
  Subcellular Imaging of Dynamic Protein Interactions by Bioluminescence Resonance Energy Transfer; Biophysical Journal 94:1001-1009 (2008)
Dual-Luciferase Assay: Chen et al.(2008):
  Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity; RNA (2008), 14:263-274
BRET: Feng et al.(2008):
  Cytoplasmic terminus of a vacuolar type proton pump accessory subunit Ac45 is required for proper interaction with V0 domain subunits and efficient osteoclastic bone resorption; J. Biol. Chem, 10.1074/jbc.M709712200
ROS assay with DCFDA fluorescence: Schmidt et al.(2008):
  The uraemic toxin phenylacetic acid increases the formation of reactive oxygen species in vascular smooth muscle cells; Nephrology Dialysis Transplantation 2008 23(1):65-71
Chemiluminescence: Nakashima et al.(2008):
  A Prodigiosin Analogue Inactivates NADPH Oxidase in Macrophage Cells by Inhibiting Assembly of p47phox and Rac; Journal of Biochemistry 2008 143(1):107-115
Caspase Assays: Christenson et al.(2008):
  Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1; Journal of Leukocyte Biology 2008; 83:139-148
Chemiluminescence: Ziegler et al.(2008):
  Dehydroepiandrosterone Induces a Neuroendocrine Phenotype in Nerve Growth Factor-Stimulated Chromaffin Pheochromocytoma PC12 Cells; Endocrinology Vol. 149, No. 1 320-328
Calcium Assay with Fura: Harzenetter et al.(2007):
  Negative Regulation of TLR Responses by the Neuropeptide CGRP Is Mediated by the Transcriptional Repressor ICER; The Journal of Immunology, 2007, 179: 607-615
BRET: Héroux et al.(2007):
  Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1; J. Biol. Chem., Vol. 282, Issue 43, 31610-31620, October 26, 2007
Fluorescence: Vallet et al.(2007):
  MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclastis; Blood, 15 November 2007, Vol. 110, No. 10, pp. 3744-3752
Luciferase Assay: Diaz et al.(2007):
  p160 Myb-Binding Protein Interacts with Prep1 and Inhibits Its Transcriptional Activity; Molecular and Cellular Biology, November 2007, p. 7981-7990, Vol. 27, No. 22
BRET: Hamdan et al.(2007):
  Unraveling G Protein-coupled Receptor Endocytosis Pathways Using Real-time Monitoring of Agonist-promoted Interaction between beta-Arrestins and AP-2; J. Biol. Chem., Vol. 282, Issue 40, 29089-29100, October 5, 2007
Fluorescence: Patschan et al.(2007):
  MAPPING MECHANISMS AND CHARTING TIME COURSE OF PREMATURE SENESCENCE AND APOPTOSIS: LYSOSOMAL DYSFUNCTION AND GANGLIOSIDE ACCUMULATION IN ENDOTHELIAL CELLS; Am J Physiol Renal Physiol October 10, 2007
Cellular Chemiluminescence: Thoren et al.(2007):
  The CD16–/CD56bright Subset of NK Cells Is Resistant to Oxidant-Induced Cell Death; The Journal of Immunology, 2007, 179: 781-785.
Phospholipase D Assay with Amplex Red: Zeniou-Meyer et al. (2007):
  Phospholipase D1 Production of Phosphatidic Acid at the Plasma Membrane Promotes Exocytosis of Large Dense-core Granules at a Late Stage; J. Biol. Chem., Vol. 282, Issue 30, 21746-21757, July 27, 2007
BRET: Quaynor et al.(2007):
  Expression of a Functional G Protein-Coupled Receptor 54-Kisspeptin Autoregulatory System in Hypothalamic Gonadotropin-Releasing Hormone Neurons; Molecular Endocrinology 21 (12): 3062-3070
BRET: Tan et al.(2007):
  Monitoring Interactions between Receptor Tyrosine Kinases and Their Downstream Effector Proteins in Living Cells Using Bioluminescence Resonance Energy Transfer; Mol Pharmacol 72:1440-1446, 2007
Fluorescence: Catalano et al.(2007):
  Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines; Endocrine-Related Cancer 14 (3) 839-845
Apoptosis with AFC: Lee at al.(2007):
  Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells; Am J Physiol Cell Physiol 293: C839-C847, 2007
Luciferase Assay: Fonseca et al.(2007):
  A Polymorphism in the CTGF Promoter Region Associated with Systemic Sclerosis; The New England Journal of Medicine, Sep 2007, 357: 1210 - 1220
Cellular Chemiluminescence: Ziegler et al.(2007):
  Dehydroepiandrosterone (DHEA) induces a neuroendocrine phenotype in nerve growth factor (NGF)-stimulated chromaffin pheochromocytoma PC12 cells; Endocrinology, doi:10.1210/en.2007-0645
Luminescence: Zhou et al.(2007):
  Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate; PNAS, September 25, 2007, vol. 104, no. 39, 15555-15559
Fluorescence: Wei et al.(2007):
  Enhanced Lysosomal Pathology Caused by beta-Synuclein Mutants Linked to Dementia with Lewy Bodies; J. Biol. Chem., Vol. 282, Issue 39, 28904-28914, September 28, 2007
Dual-Luciferase Assay: Gradisar et al.(2007):
  MD-2 as the target of curcumin in the inhibition of response to LPS; Journal of Leukocyte Biology. 2007;82:968-974
Luminescence: Bettenbrock et al.(2007):
  Correlation between Growth Rates, EIIACrr Phosphorylation, and Intracellular Cyclic AMP Levels in Escherichia coli K-12; Journal of Bacteriology, October 2007, p. 6891-6900, Vol. 189, No. 19
BRET: Coulon et al.(2007):
  SUBCELLULAR IMAGING OF DYNAMIC PROTEIN INTERACTIONS BY BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; Biophys. J.; doi:10.1529/biophysj.107.117275
BRET: Sohy et al.(2007):
  Allosteric Transinhibition by Specific Antagonists in CCR2/CXCR4 Heterodimers; J. Biol. Chem., Vol. 282, Issue 41, 30062-30069, October 12, 2007
BRET: Jorgensen et al.(2007):
  Characterization of G-Protein Coupled Receptor Kinase Interaction with the NK-1 Receptor Using BRET, Molecular Pharmacology November 6, 2007 doi:10.1124/mol.107.038877
Luciferase Assay: Takeda et al.(2007):
  A Human Lung Carcinoma Cell Line Supports Efficient Measles Virus Growth and Syncytium Formation via a SLAM- and CD46-Independent Mechanism; Journal of Virology, November 2007, p. 12091-12096, Vol. 81, No. 21
BRET: Turu et al.(2007):
  The Role of Diacylglycerol Lipase in Constitutive and Angiotensin AT1 Receptor-stimulated Cannabinoid CB1 Receptor Activity; J. Biol. Chem., Vol. 282, Issue 11, 7753-7757
Dual-Luciferase-Assay: Haim et al.(2007):
  Time Frames for Neutralization during the Human Immunodeficiency Virus Type 1 Entry Phase, as Monitored in Synchronously Infected Cell Cultures; Journal of Virology, April 2007, p. 3525-3534, Vol. 81, No. 7
BRET: Lupien et al.(2007):
  Raloxifene and ICI182,780 Increase Estrogen Receptor- Association with a Nuclear Compartment via Overlapping Sets of Hydrophobic Amino Acids in Activation Function 2 Helix 12; Molecular Endocrinology 21 (4): 797-816
Luminescence Immunoassay: Bogan et al.(2007):
  Constitutive Steroidogenesis in Ovine Large Luteal Cells May Be Mediated by Tonically Active Protein Kinase A; Biol Reprod 2007, 10.1095/biolreprod.106.059618
Luciferase Assay: Willige et al.(2007):
  The DELLA Domain of GA INSENSITIVE Mediates the Interaction with the GA INSENSITIVE DWARF1A Gibberellin Receptor of Arabidopsis; The Plant Cell 10.1105/tpc.107.051441
Chemiluminescence: Tahara et al.(2007):
  Altered Interaction of the Matrix Protein with the Cytoplasmic Tail of Hemagglutinin Modulates Measles Virus Growth by Affecting Virus Assembly and Cell-Cell Fusion; J. Virol. doi:10.1128/JVI.00248-07
Secretory transport with rhodamine 123 fluorescence: Yamagata et al.(2007):
 

Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein (BCRP), by Excipients;
J. Biol. Chem., Vol. 282, Issue 8, 5736-5748
BRET: Fessart et al.(2007):
  Src-dependent phosphorylation of 2-adaptin dissociates the -arrestin-AP-2 complex; Journal of Cell Science doi: 10.1242/jcs.03444
NADH Fluorescence: Ueo et al. (2007):
  Cl--Dependent up-regulation of human organic anion transporters: Different effects on transport kinetics between hOAT1 and hOAT3; Am J Physiol Renal Physiol, April 11, 2007
Enzyme activity of Proteasome and Cathepsin B: Fujita et al.(2007):
  a-Synuclein Stimulates Differentiation of Osteosarcoma Cells: RELEVANCE TO DOWN-REGULATION OF PROTEASOME ACTIVITY; J. Biol. Chem., Vol. 282, Issue 8, 5736-5748
BRET: Berchiche et al.(2007):
  Direct Assessment of CXCR4 Mutant Conformations Reveals Complex Link between Receptor Structure and Gi Activation; J. Biol. Chem., Vol. 282, Issue 8, 5111-5115, February 23, 2007
BRET: Jorgensen et al.(2007):
  Oxyntomodulin differentially affects Glucagon-Like Peptide-1 receptor beta-arrestin recruitment and signaling through G-alpha-s; Journal of Pharmacology And Experimental Therapeutics, DOI: 10.1124/jpet.107.120006
Reactive oxygen species (cellular luminescence) + DHR fluorescence: Mauch et al.(2007):
  Chronic Granulomatous Disease (CGD) and Complete Myeloperoxidase Deficiency Both Yield Strongly Reduced Dihydrorhodamine 123 Test Signals but Can Be Easily Discerned in Routine Testing for CGD; Clinical Chemistry clinchem.2006.083444v1, 2007
BRET: Elster et al.(2007):
  Bioluminescence Resonance Energy Transfer as a Screening Assay: Focus on Partial and Inverse Agonism; Journal of Biomolecular Screening, Vol. 12, No. 1, 41-49 (2007)
Cytotoxicity + Absorbance: Sicard et al.(2007):
  Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate; PNAS, vol. 104, no. 6 , 2007-2012 

 
BRET: Holst et al.(2007):
  GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin; Endocrinology Vol. 148, No. 1 13-20
Dual-Luciferase-Assay: Haim et al.(2007):
  Time Frames of Neutralization During the HIV-1 Entry Phase, as Monitored in Synchronously Infected Cell Cultures; J. Virol. doi:10.1128/JVI.02293-06
BRET: Schiffer et a.(2007):
  Pharmacology and Signaling Properties of Epidermal Growth Factor Receptor Isoforms Studied by Bioluminescence Resonance Energy Transfer; Mol Pharmacol 71:508-518, 2007
BRET: Turu et al.(2007):
  The role of diacylgycerol lipase in constitutive and angiotensin AT1 receptor-stimulated cannabinoid CB1 receptor activity; J. Biol. Chem, 10.1074/jbc.C600318200
BRET + Luciferase Assay + ELISA: AYOUB et al.(2007):
  Real-time analysis of agonist-induced activation of protease-activated receptor 1/Gi1 protein complex measured by BRET in living cells; Molecular Pharmacology DOI: 10.1124/mol.106.030304
Chemiluminescence with Acridinium Ester: Adamczyk et al. (2006):
  Choline Concentration in Normal Blood Donor and Cardiac Troponin–Positive Plasma Samples; Clinical Chemistry 52: 2123-2124, 2006
Dual-Luciferase-Assay: Mancek-Keber et al. (2006):
  Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2; The FASEB Journal. 2006;20:1836-1842
Fluorescence: Reiter et al. (2006):
  TRPV4-mediated regulation of epithelial permeability; The FASEB Journal. 2006;20:1802-1812
BRET: Holst et al. (2006):
  GPR39 signaling is stimulated by zinc ions but not by obestatin; Endocrinology, doi:10.1210/en.2006-0933
Luminescence: Osaki et al. (2006):
  Mutation of luxS affects motility and infectivity of Helicobacter pylori in gastric mucosa of a Mongolian gerbil model; J Med Microbiol 55 (2006), 1477-1485
BRET: Schiffer at al. (2006):
  Pharmacology and signaling properties of EGFR isoforms studied by Bioluminescence Resonance Energy Transfer (BRET); Molecular Pharmacology, DOI: 10.1124/mol.106.027656
Luciferase-Assay: Milliat et al. (2006):
  Influence of Endothelial Cells on Vascular Smooth Muscle Cells Phenotype after Irradiation: Implication in Radiation-Induced Vascular Damages; American Journal of Pathology. 2006;169:1484-1495
BRET: Mangmool et al. (2006):
  Clathrin Required for phosphorylation and internalization of 2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2); J. Biol. Chem, 10.1074/jbc.M602832200
BRET: Poulsen et al. (2006):
  Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain; RNA (2006), 12:1350-1360
FRET: Nikolaev et al. (2006):
  Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer; J. Biol. Chem, 10.1074/jbc.M603266200
Proteasome Activity by MCA Fluorescence: Hubert-Buron et al. (2006):
  Glutamine Pretreatment Reduces IL-8 Production in Human Intestinal Epithelial Cells by Limiting IB Ubiquitination; The Journal of Nutrition, 136:1461-1465, June 2006
Luciferase-Assay: Galmiche et al. (2006):
  The expression of aromatase in gonadotropes is regulated by estradiol and GnRH in a manner that differs from the regulation of LH; Endocrinology, doi:10.1210/en.2005-1650
Luciferase Assay: Nirula et al. (2006):
  Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4; The Journal of Experimental Medicine, doi:10.1084/jem.20051715
Chemiluminescence, Reporter Assay, Fluorescence with eGFP: Takeda et al. (2006):
  Generation of Measles Virus with a Segmented RNA Genome; Journal of Virology, May 2006, p. 4242-4248, Vol. 80, No. 9
ATP determination: Jacquard et al. (2006):
  Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation; The FASEB Journal. 2006;20:1021-1023
Luciferase Assay in plants: Calderon-Villalobos et al. (2006):
  LucTrap Vectors Are Tools to Generate Luciferase Fusions for the Quantification of Transcript and Protein Abundance in Vivo; Plant Physiology 141:3-14 (2006)
Dual-Luciferase-Assay: Fujimura et al. (2006):
  A selective peroxisome proliferator-activated receptor  modulator with distinct fat cell regulation properties; Journal of Pharmacology And Experimental Therapeutics, DOI: 10.1124/jpet.106.102459
Fluorescence Measurements of YFP expression: Burstein et al. (2006):
  Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors; British Journal of Pharmacology (2006) 147, 73–82
Chemiluminescence in liver tissues (Reactive Oxygen Species): Katzenellenbogen et al. (2006):
  Multiple Adaptive Mechanisms to Chronic Liver Disease Revealed at Early Stages of Liver Carcinogenesis in the Mdr2-Knockout Mice; Cancer Research 66, 4001-4010
BRET: Sirokmány et al. (2006):
  Sec14 Homology Domain Targets p50RhoGAP to Endosomes and Provides a Link between Rab and Rho GTPases; J. Biol. Chem., Vol. 281, Issue 9, 6096-6105
BRET: Qazi et al. (2006):
  Ligand-Independent Homo- and Hetero-Dimerization of Human Prolactin Receptor Variants: Inhibitory Action of the Short Forms by Heterodimerization; Molecular Endocrinology, doi:10.1210/me.2005-0291